Can train alone to reverse type 2 diabetes

Prevention of cardiovascular disease through exercise and physical activity

  • 1.

    Lozano R, Naghavi M, Foreman K et al (2012) Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380 (9859): 2095 -2128

    ArticlePubMed Google Scholar

  • 2.

    Lee DC, Pate RR, Lavie CJ et al (2014) Leisure-time running reduces all-cause and cardiovascular mortality risk. J Am Coll Cardiol 64 (5): 472-481

    ArticlePubMed Google Scholar

  • 3.

    Lavie CJ, McAuley PA, Church TS et al (2014) Obesity and cardiovascular diseases: implications regarding fitness, fatness, and severity in the obesity paradox. J Am Coll Cardiol 63 (14): 1345-1354

    ArticlePubMed Google Scholar

  • 4.

    Khan KM, Thompson AM, Blair SN et al (2012) Sport and exercise as contributors to the health of nations. Lancet 380 (9836): 59-64

    ArticlePubMed Google Scholar

  • 5.

    Sui X, Hooker SP, Lee IM et al (2008) A prospective study of cardiorespiratory fitness and risk of type 2 diabetes in women. Diabetes Care 31 (3): 550-555

    ArticlePubMed CentralPubMed Google Scholar

  • 6.

    Unick JL, Beavers D, Jakicic JM et al (2011) Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes: results from the look AHEAD trial. Diabetes Care 34 (10): 2152-2157

    ArticlePubMed CentralPubMed Google Scholar

  • 7.

    Oldridge NB (2008) Economic burden of physical inactivity: healthcare costs associated with cardiovascular disease. Eur J Cardiovasc Prev Rehabil 15 (2): 130-139

    ArticlePubMed Google Scholar

  • 8.

    Lee IM, Shiroma EJ, Lobelo F et al (2012) Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 380 (9838): 219-229

    ArticlePubMed CentralPubMed Google Scholar

  • 9.

    Sattelmair J, Pertman J, Ding EL et al (2011) Dose response between physical activity and risk of coronary heart disease: a meta-analysis. Circulation 124 (7): 789-795

    ArticlePubMed CentralPubMed Google Scholar

  • 10.

    Berry JD, Willis B, Gupta S et al (2011) Lifetime risks for cardiovascular disease mortality by cardiorespiratory fitness levels measured at ages 45, 55, and 65 years in men. The Cooper Center Longitudinal Study. J Am Coll Cardiol 57 (15): 1604-1610

    ArticlePubMed CentralPubMed Google Scholar

  • 11.

    Gupta S, Rohatgi A, Ayers CR et al (2011) Cardiorespiratory fitness and classification of risk of cardiovascular disease mortality. Circulation 123 (13): 1377-1383

    ArticlePubMed CentralPubMed Google Scholar

  • 12.

    Blair SN, Kohl HW III, Paffenbarger RS ​​Jr et al (1989) Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 262 (17): 2395-2401

    ArticleCASPubMed Google Scholar

  • 13.

    Myers J, Prakash M, Froelicher V et al (2002) Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 346 (11): 793-801

    ArticlePubMed Google Scholar

  • 14.

    Schuler G, Adams V, Goto Y (2013) Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives. Eur Heart J 34 (24): 1790-1799

    ArticleCASPubMed Google Scholar

  • 15.

    Laursen AH, Kristiansen OP, Marott JL et al (2012) Intensity versus duration of physical activity: implications for the metabolic syndrome. A prospective cohort study. BMJ Open 2 (5)

  • 16.

    Petersen CB, Gronbaek M, Helge JW et al (2012) Changes in physical activity in leisure time and the risk of myocardial infarction, ischemic heart disease, and all-cause mortality. Eur J Epidemiol 27 (2): 91-99

    ArticlePubMed Google Scholar

  • 17.

    Schnohr P, Marott JL, Jensen JS, Jensen GB (2012) Intensity versus duration of cycling, impact on all-cause and coronary heart disease mortality: the Copenhagen City Heart Study. Eur J Prev Cardiol 19 (1): 73-80

    ArticlePubMed Google Scholar

  • 18.

    Wen CP, Wai JP, Tsai MK et al (2011) Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet 378 (9798): 1244-1253

    ArticlePubMed Google Scholar

  • 19.

    Hahn V, Halle M, Schmidt-Trucksass A et al (2009) Physical activity and the metabolic syndrome in elderly German men and women: results from the population-based KORA survey. Diabetes Care 32 (3): 511-513

    ArticlePubMed CentralPubMed Google Scholar

  • 20.

    Dohm GL (2002) Invited review: regulation of skeletal muscle GLUT-4 expression by exercise. J Appl Physiol 93 (2): 782-787

    ArticleCASPubMed Google Scholar

  • 21.

    Duncan GE, Perri MG, Theriaque DW et al (2003) Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care 26 (3): 557-562

    ArticleCASPubMed Google Scholar

  • 22.

    Steppan J, Sikka G, Jandu S et al (2014) Exercise, vascular stiffness, and tissue transglutaminase. J Am Heart Assoc 3 (2): e000599

    ArticlePubMed CentralPubMed Google Scholar

  • 23.

    Adams V, Besler C, Fischer T et al (2013) Exercise training in patients with chronic heart failure promotes restoration of high-density lipoprotein functional properties. Circ Res 113 (12): 1345-1355

    ArticleCASPubMed Google Scholar

  • 24.

    Weber M, Baker MB, Moore JP, Searles CD (2010) MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity. Biochem Biophys Res Commun 393 (4): 643-648

    ArticlePubMed CentralCASPubMed Google Scholar

  • 25.

    Volaklis KA, Tokmakidis SP, Halle M (2013) Acute and chronic effects of exercise on circulating endothelial progenitor cells in healthy and diseased patients. Clin Res Cardiol 102 (4): 249-257

    ArticlePubMed Google Scholar

  • 26.

    Laufs U, Urhausen A, Werner N et al (2005) Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects. Eur J Cardiovasc Prev Rehabil 12 (4): 407-414

    ArticlePubMed Google Scholar

  • 27.

    Edelmann F, Gelbrich G, Dungen HD et al (2011) Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study. J Am Coll Cardiol 58 (17): 1780-1791

    ArticlePubMed Google Scholar

  • 28.

    Stone NJ, Robinson JG, Lichtenstein AH et al (2014) 2013 ACC / AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology / American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 63 (25 Pt B): 2889-2934

    ArticlePubMed Google Scholar

  • 29.

    Eckel RH, Jakicic JM, Ard JD et al (2014) 2013 AHA / ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology / American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 63 (25 Pt B): 2960-2984

    ArticlePubMed Google Scholar

  • 30.

    Vanhees L, Geladas N, Hansen D et al (2012) Importance of characteristics and modalities of physical activity and exercise in the management of cardiovascular health in individuals with cardiovascular risk factors: recommendations from the EACPR. Part II. Eur J Prev Cardiol 19 (5): 1005-1033

    ArticleCASPubMed Google Scholar

  • 31.

    Cornelissen VA, Smart NA (2013) Exercise training for blood pressure: a systematic review and meta-analysis. J Am Heart Assoc 2 (1): e004473

    ArticlePubMed CentralPubMed Google Scholar

  • 32.

    Church TS, Kampert JB, Gibbons LW et al (2001) Usefulness of cardiorespiratory fitness as a predictor of all-cause and cardiovascular disease mortality in men with systemic hypertension. Am J Cardiol 88 (6): 651-656

    ArticleCASPubMed Google Scholar

  • 33.

    Molmen-Hansen HE, Stolen T, Tjonna AE et al (2012) Aerobic interval training reduces blood pressure and improves myocardial function in hypertensive patients. Eur J Prev Cardiol 19 (2): 151-160

    ArticlePubMed Google Scholar

  • 34.

    Lindström J, Louheranta A, Mannelin M et al (2003) The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care 26 (12): 3230-3236

    ArticlePubMed Google Scholar

  • 35.

    Knowler WC, Barrett-Connor E, Fowler SE et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346 (6): 393-403

    ArticleCASPubMed Google Scholar

  • 36.

    Lindström J, Ilanne-Parikka P, Peltonen M et al (2006) Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet 368 (9548): 1673-1679

    ArticlePubMed Google Scholar

  • 37.

    Tuomilehto J, Lindström J, Eriksson JG et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344 (18): 1343-1350

    ArticleCASPubMed Google Scholar

  • 38.

    Lindström J, Peltonen M, Eriksson JG et al (2013) Improved lifestyle and decreased diabetes risk over 13 years: long-term follow-up of the randomized Finnish Diabetes Prevention Study (DPS). Diabetologia 56 (2): 284-293

    ArticlePubMed Google Scholar

  • 39.

    Tjonna AE, Lee SJ, Rognmo O et al (2008) Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation 118 (4): 346-354

    ArticlePubMed CentralPubMed Google Scholar

  • 40.

    Karstoft K, Winding K, Knudsen SH et al (2013) The effects of free-living interval-walking training on glycemic control, body composition, and physical fitness in type 2 diabetes patients: a randomized, controlled trial. Diabetes Care 36 (2): 228-236

    ArticlePubMed CentralPubMed Google Scholar

  • 41.

    Gibala MJ, Little JP, MacDonald MJ, Hawley JA (2012) Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol 590 (Pt 5): 1077-1084

    ArticlePubMed CentralCASPubMed Google Scholar

  • 42.

    Kraus WE, Houmard JA, Duscha BD et al (2002) Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med 347 (19): 1483-1492

    ArticleCASPubMed Google Scholar

  • 43.

    Wadden TA, Neiberg RH, Wing RR et al (2011) Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity (Silver Spring) 19 (10): 1987-1998

  • 44.

    Rejeski WJ, Bray GA, Chen SH et al (2015) Aging and physical function in type 2 diabetes: 8 years of an intensive lifestyle intervention. J Gerontol A Biol Sci Med Sci 70 (3): 343-351

    Google Scholar

  • 45.

    Kelley GA, Kelley KS (2007) Effects of aerobic exercise on lipids and lipoproteins in adults with type 2 diabetes: a meta-analysis of randomized-controlled trials. Public Health 121 (9): 643-655

    ArticlePubMed CentralCASPubMed Google Scholar

  • 46.

    Halle M, Berg A, Garwers U et al (1999) Influence of 4 weeks ‘intervention by exercise and diet on low-density lipoprotein subfractions in obese men with type 2 diabetes. Metabolism 48 (5): 641-644

    ArticleCASPubMed Google Scholar

  • 47.

    Mohlenkamp S, Lehmann N, Breuckmann F et al (2008) Running: the risk of coronary events: prevalence and prognostic relevance of coronary atherosclerosis in marathon runners. Eur Heart J 29 (15): 1903-1910

    ArticlePubMed Google Scholar

  • 48.

    Heidbuchel H, La GA (2012) The right heart in athletes. Evidence for exercise-induced arrhythmogenic right ventricular cardiomyopathy. Cardiac Pacemaker Electrophysiol 23 (2): 82-86

    CASPubMed Google Scholar

  • 49.

    O’Keefe JH, Schnohr P, Lavie CJ (2013) The dose of running that best confers longevity. Heart 99 (8): 588-590

    Google Scholar

  • 50.

    Schnohr P, O’Keefe JH, Marott JL et al (2015) Dose of jogging and long-term mortality. J Am Coll Cardiol 65 (5): 411-419

    ArticlePubMed Google Scholar

  • 51.

    Scherr J, Braun S, Schuster T et al (2011) 72-h kinetics of high-sensitive troponin T and inflammatory markers after marathon. Med Sci Sports Exerc 43 (10): 1819-1827

    ArticleCASPubMed Google Scholar

  • 52.

    La GA, Burns AT, Mooney DJ et al (2012) Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes. Eur Heart J 33 (8): 998-1006

    Article Google Scholar

  • 53.

    Mohlenkamp S, Leineweber K, Lehmann N et al (2014) Coronary atherosclerosis burden, but not transient troponin elevation, predicts long-term outcome in recreational marathon runners. Basic Res Cardiol 109 (1): 391

    ArticlePubMed Google Scholar

  • 54.

    Wernhart S, Halle M (2014) Atrial fibrillation and long-term sports practice: epidemiology and mechanisms. Clin Res Cardiol [Epub ahead of print]

  • 55.

    Schnohr P, Marott JL, Lange P, Jensen GB (2013) Longevity in male and female joggers: the Copenhagen City Heart Study. Am J Epidemiol 177 (7): 683-689

    ArticlePubMed Google Scholar

  • 56.

    Weston KS, Wisloff U, Coombes JS (2014) High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med 48 (16): 1227-1234

    ArticlePubMed Google Scholar

  • 57.

    Rognmo Ø, Moholdt T, Bakken H et al (2012) Cardiovascular risk of high- versus moderate-intensity aerobic exercise in coronary heart disease patients. Circulation 126 (12): 1436-1440

    ArticlePubMed Google Scholar

  • 58.

    Halle M (2013) Letter by Halle regarding article, "Cardiovascular risk of high- versus moderate-intensity aerobic exercise in coronary heart disease patients". Circulation 127 (21): e637

    ArticlePubMed Google Scholar